Gait and balance disorders in Parkinson's disease: Impaired active braking of the fall of centre of gravity
Identifieur interne : 002295 ( Main/Exploration ); précédent : 002294; suivant : 002296Gait and balance disorders in Parkinson's disease: Impaired active braking of the fall of centre of gravity
Auteurs : Nathalie Chastan [France] ; Manh Cuong Do [France] ; Fabrice Bonneville [France] ; Frédéric Torny [France] ; Frédéric Bloch [France] ; G. W. Max Westby [France] ; Didier Dormont [France] ; Yves Agid [France] ; Marie-Laure Welter [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-01-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Basal Ganglia (pathology), Basal Ganglia (physiopathology), Biomechanical Phenomena, Brain (pathology), Brain (physiopathology), Case-Control Studies, Dopamine (physiology), Equilibrium disorder, Female, Gait Apraxia (etiology), Gait Apraxia (pathology), Gait Apraxia (physiopathology), Gait disorder, Gravitation, Humans, Instability, Levodopa (pharmacology), Levodopa (therapeutic use), Magnetic Resonance Imaging, Male, Mesencephalon (pathology), Mesencephalon (physiopathology), Middle Aged, Nervous system diseases, Nuclear magnetic resonance imaging, Organ Size, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Postural Balance (drug effects), Postural Balance (physiology), Sensation Disorders (etiology), Sensation Disorders (pathology), Sensation Disorders (physiopathology), Walking (physiology), gait initiation, magnetic resonance imaging, postural instability.
- MESH :
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- chemical , physiology : Dopamine.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- complications : Parkinson Disease.
- drug effects : Postural Balance.
- drug therapy : Parkinson Disease.
- etiology : Gait Apraxia, Sensation Disorders.
- pathology : Basal Ganglia, Brain, Gait Apraxia, Mesencephalon, Parkinson Disease, Sensation Disorders.
- physiology : Postural Balance, Walking.
- physiopathology : Basal Ganglia, Brain, Gait Apraxia, Mesencephalon, Parkinson Disease, Sensation Disorders.
- Biomechanical Phenomena, Case-Control Studies, Female, Gravitation, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size.
Abstract
Gait and balance disorders are common in Parkinson's disease (PD), but its pathophysiology is still poorly understood. Step length, antero‐posterior, and vertical velocities of the center of gravity (CG) during gait initiation were analyzed in 32 controls and 32 PD patients, with and without levodopa, using a force platform. Brain volumes and mesencephalic surface area were measured in PD patients. During the swing limb period, controls showed a fall in the CG, which was reversed before foot‐contact indicating active braking of the CG fall. In PD patients, without levodopa, step length and velocity were significantly reduced and no braking occurred before foot‐contact in 22 patients. With levodopa, step length and velocity increased in all patients and 7 patients improved their braking capacity. PD patients with normal braking (n = 17) had significantly lower gait and balance disorder scores and higher normalized‐mesencephalic surface areas compared to patients with impaired braking (n = 15). The decreased step length and velocity, characteristic of PD, mainly result from degeneration of central dopaminergic systems. The markedly decreased braking capacity observed in half the PD patients contributes to their gait disorders and postural instability, perhaps as a result of nondopaminergic lesions, possibly at the mesencephalic level. © 2008 Movement Disorder Society
Url:
- https://api.istex.fr/document/0ED61862F7ABEEF5D1BF780D12CC96A8747C1EFE/fulltext/pdf
- https://hal.inria.fr/hal-00805424
- https://hal.archives-ouvertes.fr/hal-00583632
DOI: 10.1002/mds.22269
Affiliations:
- France
- Île-de-France
- Orsay, Paris, Rouen
- Hôpital de la Salpêtrière, Université Paris-Sud, Université Pierre-et-Marie-Curie
Links toward previous steps (curation, corpus...)
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<term>Antiparkinson Agents (therapeutic use)</term>
<term>Basal Ganglia (pathology)</term>
<term>Basal Ganglia (physiopathology)</term>
<term>Biomechanical Phenomena</term>
<term>Brain (pathology)</term>
<term>Brain (physiopathology)</term>
<term>Case-Control Studies</term>
<term>Dopamine (physiology)</term>
<term>Equilibrium disorder</term>
<term>Female</term>
<term>Gait Apraxia (etiology)</term>
<term>Gait Apraxia (pathology)</term>
<term>Gait Apraxia (physiopathology)</term>
<term>Gait disorder</term>
<term>Gravitation</term>
<term>Humans</term>
<term>Instability</term>
<term>Levodopa (pharmacology)</term>
<term>Levodopa (therapeutic use)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Mesencephalon (pathology)</term>
<term>Mesencephalon (physiopathology)</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Organ Size</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Postural Balance (drug effects)</term>
<term>Postural Balance (physiology)</term>
<term>Sensation Disorders (etiology)</term>
<term>Sensation Disorders (pathology)</term>
<term>Sensation Disorders (physiopathology)</term>
<term>Walking (physiology)</term>
<term>gait initiation</term>
<term>magnetic resonance imaging</term>
<term>postural instability</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Postural Balance</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Apraxia</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Brain</term>
<term>Gait Apraxia</term>
<term>Mesencephalon</term>
<term>Parkinson Disease</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postural Balance</term>
<term>Walking</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Brain</term>
<term>Gait Apraxia</term>
<term>Mesencephalon</term>
<term>Parkinson Disease</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Biomechanical Phenomena</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Gravitation</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Organ Size</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Imagerie RMN</term>
<term>Instabilité</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Trouble de l'équilibre</term>
<term>Trouble de la marche</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Gait and balance disorders are common in Parkinson's disease (PD), but its pathophysiology is still poorly understood. Step length, antero‐posterior, and vertical velocities of the center of gravity (CG) during gait initiation were analyzed in 32 controls and 32 PD patients, with and without levodopa, using a force platform. Brain volumes and mesencephalic surface area were measured in PD patients. During the swing limb period, controls showed a fall in the CG, which was reversed before foot‐contact indicating active braking of the CG fall. In PD patients, without levodopa, step length and velocity were significantly reduced and no braking occurred before foot‐contact in 22 patients. With levodopa, step length and velocity increased in all patients and 7 patients improved their braking capacity. PD patients with normal braking (n = 17) had significantly lower gait and balance disorder scores and higher normalized‐mesencephalic surface areas compared to patients with impaired braking (n = 15). The decreased step length and velocity, characteristic of PD, mainly result from degeneration of central dopaminergic systems. The markedly decreased braking capacity observed in half the PD patients contributes to their gait disorders and postural instability, perhaps as a result of nondopaminergic lesions, possibly at the mesencephalic level. © 2008 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Orsay</li>
<li>Paris</li>
<li>Rouen</li>
</settlement>
<orgName><li>Hôpital de la Salpêtrière</li>
<li>Université Paris-Sud</li>
<li>Université Pierre-et-Marie-Curie</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name>
</noRegion>
<name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<name sortKey="Bloch, Frederic" sort="Bloch, Frederic" uniqKey="Bloch F" first="Frédéric" last="Bloch">Frédéric Bloch</name>
<name sortKey="Bloch, Frederic" sort="Bloch, Frederic" uniqKey="Bloch F" first="Frédéric" last="Bloch">Frédéric Bloch</name>
<name sortKey="Bloch, Frederic" sort="Bloch, Frederic" uniqKey="Bloch F" first="Frédéric" last="Bloch">Frédéric Bloch</name>
<name sortKey="Bonneville, Fabrice" sort="Bonneville, Fabrice" uniqKey="Bonneville F" first="Fabrice" last="Bonneville">Fabrice Bonneville</name>
<name sortKey="Bonneville, Fabrice" sort="Bonneville, Fabrice" uniqKey="Bonneville F" first="Fabrice" last="Bonneville">Fabrice Bonneville</name>
<name sortKey="Bonneville, Fabrice" sort="Bonneville, Fabrice" uniqKey="Bonneville F" first="Fabrice" last="Bonneville">Fabrice Bonneville</name>
<name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name>
<name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name>
<name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name>
<name sortKey="Do, Manh Cuong" sort="Do, Manh Cuong" uniqKey="Do M" first="Manh Cuong" last="Do">Manh Cuong Do</name>
<name sortKey="Do, Manh Cuong" sort="Do, Manh Cuong" uniqKey="Do M" first="Manh Cuong" last="Do">Manh Cuong Do</name>
<name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name>
<name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name>
<name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name>
<name sortKey="Torny, Frederic" sort="Torny, Frederic" uniqKey="Torny F" first="Frédéric" last="Torny">Frédéric Torny</name>
<name sortKey="Torny, Frederic" sort="Torny, Frederic" uniqKey="Torny F" first="Frédéric" last="Torny">Frédéric Torny</name>
<name sortKey="Torny, Frederic" sort="Torny, Frederic" uniqKey="Torny F" first="Frédéric" last="Torny">Frédéric Torny</name>
<name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<name sortKey="Westby, G W Max" sort="Westby, G W Max" uniqKey="Westby G" first="G. W. Max" last="Westby">G. W. Max Westby</name>
<name sortKey="Westby, G W Max" sort="Westby, G W Max" uniqKey="Westby G" first="G. W. Max" last="Westby">G. W. Max Westby</name>
<name sortKey="Westby, G W Max" sort="Westby, G W Max" uniqKey="Westby G" first="G. W. Max" last="Westby">G. W. Max Westby</name>
</country>
</tree>
</affiliations>
</record>
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